Medical Management and Strategies to Prevent Coronary Artery Disease in Patients With Type 2 Diabetes Mellitus

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Mae Sheikh-Ali, MD; Prafull Raheja, MD; Nancy Borja-Hart, PharmD, BCPS

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Postgraduate Medicine:

Volume 125 No. 1


Clinical Focus

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DOI: 10.3810/pgm.2013.01.2621
Abstract: Coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM) is associated with increased immediate and long-term mortality compared with patients without T2DM. The amplified incidence of CAD stems partly from the aggregation of multiple risk factors, such as obesity, dyslipidemia, and hypertension, which occur in this population. In addition, there appear to be increased forces at play at the molecular and vascular levels in these individuals, which is evidenced by the increased thrombosis and inflammation that is seen in those with diabetic atherosclerosis. Hence, there is a growing need to emphasize early and vigilant risk factor management in patients with T2DM to help reduce their burden of cardiovascular-related mortality. In this article, we review the primary and secondary prevention measures as well as the management of CAD in patients with T2DM.

Keywords: coronary artery disease; type 2 diabetes mellitus; coronary artery disease management; primary prevention; secondary prevention