ANTIDEPRESSANT DRUG INTERACTIONS IN THE ELDERLY

Understanding the P-450 system is half the battle in reducing risks

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Roger J. Cadieux, MD

Table of Contents

Postgraduate Medicine:

Volume 106 No. 6

Category:

Clinical Features

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DOI: 10.3810/pgm.1999.11.780
Abstract: As patients age, pharmacologic treatment of depression becomes more complicated because of the increased risk of drug interactions in the elderly. Choosing an appropriate agent requires a thorough knowledge of cytochrome P-450 enzymes, which affect drug metabolism in the liver. In this article, Dr Cadieux explains the critical factors affecting antidepressant treatment in elderly patients and discusses potential and documented drug interactions of selected agents.

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