WHEN TO TRY COX-2-SPECIFIC INHIBITORS

Safer than standard NSAIDs in some situations

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Qaiser Rehman, MD, Kenneth E. Sack, MD

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Postgraduate Medicine:

Volume 106 No. 4

Category:

Clinical Focus

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DOI: 10.3810/pgm.1999.10.1.704
Abstract: Cyclooxygenase-2 (COX-2) inhibitors are the latest addition to the growing armamentarium of anti-inflammatory drugs. Their ability to selectively block formation of proinflammatory prostaglandins while sparing those that guard the gastrointestinal tract makes them an attractive choice for long-term use, such as in rheumatic disease. More COX-2 inhibitors will undoubtedly become available, so primary care physicians should be aware of their advantages and limitations. In this article, the authors describe the pharmacokinetics and use of these agents.

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