Don't forget to look at the urine

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Michael W. Rich, MD

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Postgraduate Medicine:

Volume 105 No. 4


Clinical Features

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DOI: 10.3810/pgm.1999.04.691
Abstract: Porphyrias result from inherited or acquired deficiencies in any one of several enzymes that synthesize heme. When a given enzyme is absent or in short supply, porphyrins are shunted away from heme synthesis into pathways that produce porphyrin by-products. These by-products, in turn, build up in tissues and cause the clinical manifestations of porphyria. In this case report, Dr Rich discusses findings in a patient with porphyria cutanea tarda and provides valuable information for recognizing and treating this disorder.